Hydrochloric Acid → HCID 3062233, compound

HRID 1995752Notes

Reaction equation

HRID 1995752 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH2:11][CH2:12][CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1)=[CH:8][CH:7]=[CH:6][CH:5]=2.[OH-].[Na+].Cl.[CH:22]([Cl:25])(Cl)Cl>[Cl-].C([N+](CC)(CC)CC1C=CC=CC=1)C.O>[CH3:1][C:2]1[C:22]([Cl:25])=[C:10]([CH2:11][CH2:12][CH:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 12674083HCID 12674083, compound

Product 1

HCID 3062233HCID 3062233, compound

Reagents, catalysts & solvents 2

HCID 66133Benzyl triethylammonium chlorideCatalystHCID 962WaterSolvent

Procedure

The operation is as in Example 1, but starting from 5.9 g of 4-[2-(2-methyl-3-indolyl)-ethyl]-piperidine and 0.12 g of triethylbenzylammonium chloride in 60 ml of chloroform and 7.5 g of sodium hydroxide in 15 ml of water. 2.7 g of 2-methyl-3-chloro-4-[2-(4-piperidyl)-ethyl]-quinoline are finally obtained in the form of the monohydrochloride which melts at 255° C.

Sources & evidence

ORD record
ord-2534e62472c64f1488fe0a6f3dd47da8
Source dataset
uspto-grants-1983_09
Patent number
US04405789

Reaction notes

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