Hydrochloric Acid → HCID 3062235, compound

HRID 1995753Notes

Reaction equation

HRID 1995753 reaction equation
[C:1]1([C:7]2[NH:8][C:9]3[C:14]([C:15]=2[CH2:16][CH2:17][CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl.[CH:27]([Cl:30])(Cl)Cl>[Cl-].C([N+](CC)(CC)CC1C=CC=CC=1)C.O>[C:1]1([C:7]2[C:27]([Cl:30])=[C:15]([CH2:16][CH2:17][CH:18]3[CH2:19][CH2:20][NH:21][CH2:22][CH2:23]3)[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 12674084HCID 12674084, compound

Product 1

HCID 3062235HCID 3062235, compound

Reagents, catalysts & solvents 2

HCID 66133Benzyl triethylammonium chlorideCatalystHCID 962WaterSolvent

Procedure

The operation is as in Example 1, but starting from 12 g of 4-[2-(2-phenyl-3-indolyl)-ethyl]-piperidine and 0.2 g of triethylbenzylammonium chloride in 110 ml of chloroform and 12 g of sodium hydroxide in 24 ml of water. 1.05 g of 2-phenyl-3-chloro-4-[2-(4-piperidyl)-ethyl]-quinoline are finally obtained in the form of the hydrochloride melting at 233° C.

Sources & evidence

ORD record
ord-b6b6f38e63b84f1c9d4ae06cd3168e34
Source dataset
uspto-grants-1983_09
Patent number
US04405789

Reaction notes

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