Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Phosphorus trichloride | HCID 24387 | — |
| Reactant | 4,4-dimethyl-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid | HCID 20439316 | — |
| Product | HCID 54561769 | HCID 54561769 | 195.8% |
Reaction Steps
102 g of 1,1-dimethyl-tetralin-4-carboxylic acid are treated while stirring with 27.4 g of phosphorus trichloride and the mixture is stirred at 50° C. for 3 hours. This treatment is carried out while excluding moisture and conducting away the resulting hydrochloric acid gas. The upper phase is separated after 12 hours and distilled over a short Vigreux column. There are obtained 87 g of 1,1-dimethyl-tetralin-4-carboxylic acid chloride of boiling point 89° C./0.2 mmHg; nD20 =1.5418-20; yield 78%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04406828 |
|---|
| Source dataset | uspto-grants-1983_09 |
|---|
| ORD ID | ord-1c4227ef67f94ba7af3770ec90e7fbda |
|---|
| Source note | uspto-grants-1983_09 |
|---|
