Hydrochloric Acid → (2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-yl)hydrazine

HRID 1995914Notes

Reaction equation

HRID 1995914 reaction equation
Cl.[CH3:2][C:3]1([CH3:18])[CH2:7][C:6]2[CH:8]=[CH:9][CH:10]=[C:11]([N:12](S(O)(=O)=O)[NH2:13])[C:5]=2[O:4]1>C(O)C>[CH3:2][C:3]1([CH3:18])[CH2:7][C:6]2[CH:8]=[CH:9][CH:10]=[C:11]([NH:12][NH2:13])[C:5]=2[O:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20449138HCID 20449138, compound

Product 1

HCID 13241352(2,2-Dimethyl-2,3-dihydro-1-benzofuran-7-yl)hydrazine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

18 g of hydrogen chloride was introduced into a stirred slurry of 56 g of (1B) in 250 ml of ethanol. The resulting mixture was stirred for 3 hours, and the solvent was evaporated. The residue was dissolved in 50 ml of water, the solution was made basic with aqueous sodium hydroxide, and extracted with ether. The extract was washed with cold water, dried (MgSO4), and filtered, and the solvent was evaporated to give 2,3-dihydro-2,2-dimethyl-7-hydrazinobenzofuran (1C) as a dark oil.

Workup

  1. customthe solvent was evaporated
  2. dissolutionThe residue was dissolved in 50 ml of water
  3. extractionextracted with ether
  4. washThe extract was washed with cold water
  5. dry with materialdried (MgSO4)
  6. filtrationfiltered
  7. customthe solvent was evaporated

Sources & evidence

ORD record
ord-adf922d6af9f4144bca41ce4c1158250
Source dataset
uspto-grants-1983_09
Patent number
US04406910

Reaction notes

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