反应详情

A mixture of (Z)-2-(2-propoxyimino)-2-(2-tritylaminothiazol-4-yl)acetic acid (IVc) (707 mg, 1.5 mmoles) and phosphorus pentachloride (344 mg, 1.65 mmoles) in dichloromethane (14 mL) was stirred at room temperature for 1 hour and poured into a solution of Compound V (677 mg, 1.5 mmoles) and BSA (1.1 mL, 4.5 mmoles) in dichloromethane (15 mL). The reaction mixture was stirred at room temperature for 30 minutes, diluted with ethyl acetate (200 mL), washed with aqueous sodium bicarbonate (100 mL) and water (3×100 mL), dried over sodium sulfate and evaporated to give 1.4 g (100%) of Compound VIc.

1. stirringThe reaction mixture was stirred at room temperature for 30 minutes
2. washwashed with aqueous sodium bicarbonate (100 mL) and water (3×100 mL)
3. dry with materialdried over sodium sulfate
4. customevaporated