HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 7-Benzyl-1-ethoxymethyl-3-methylxanthine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Chloromethyl ethyl ether | HCID 18523 | — |
| Reactant | 7-Benzyl-3-methylxanthine | HCID 685630 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-Benzyl-1-ethoxymethyl-3-methylxanthine | HCID 19689145 | — |
Reaction Steps
20 g (0.078 mol) of 7-benzyl-3-methylxanthine were stirred at 80° C. for 6 hours with 8.8 g (0.094 mol) of ethoxymethyl chloride and 13 g of potassium carbonate in 500 ml of absolute dimethylformamide, the mixture was filtered and concentrated, and the residue which remained was chromatographed (eluent: dichloromethane/methanol 20:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05728686 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-eadaded2a68a4a4683c2b0691e2f1aa0 |
| Source note | uspto-grants-1998_03 |