tert-butyl (R)-3-amino-3-methylpyrrolidine-1-carboxylate → HCID 118436056, compound

HRID 1996727Notes

Reaction equation

HRID 1996727 reaction equation
[NH2:1][c:2]1[n:7][cH:6][c:5]([c:8]2[c:13]([CH2:14][CH2:15]I)[c:12](Cl)[n:11][c:10]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)[n:9]2)[cH:4][n:3]1.[CH3:22][C:23]([O:26][C:27]([N:29]1[CH2:35][C@@:32]([NH2:34])([CH3:33])[CH2:31][CH2:30]1)=[O:28])([CH3:25])[CH3:24]>>[CH3:22][C:23]([O:26][C:27]([N:29]1[CH2:35][C@:32]([N:34]2[c:12]3[c:13]([c:8]([c:5]4[cH:6][n:7][c:2]([NH2:1])[n:3][cH:4]4)[n:9][c:10]([N:16]5[CH2:21][CH2:20][O:19][CH2:18][CH2:17]5)[n:11]3)[CH2:14][CH2:15]2)([CH3:33])[CH2:31][CH2:30]1)=[O:28])([CH3:25])[CH3:24]

Participants

6

Reactant 2

HCID 86328912tert-butyl (R)-3-amino-3-methylpyrrolidine-1-carboxylateHCID 178508375HCID 178508375, compound

Product 1

HCID 118436056HCID 118436056, compound

Reagents, catalysts & solvents 3

HCID 4339838N'''-(1,1-Dimethylethyl)-N,N',N''-tris(tris(dimethylamino)phosphoranylidene)phosphorimidic triamideReagentHCID 679Dimethyl SulfoxideSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
70 °C

Sources & evidence

ORD record
ord-48fc23bac4e14a2aac271e5bd527db47
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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