Hydrochloric Acid → beta-trimethylsilylethyl (3RS,4RS)-4-(4-fluorophenyl)-3-(4-hydroxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

HRID 199764Notes

Reaction equation

HRID 199764 reaction equation
[CH3:45][OH:46].[ClH:44].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([O:23][CH2:24][c:25]3[cH:26][c:27]4[cH:28][cH:29][cH:30][cH:31][c:32]4[c:33]([O:35][CH2:36][O:37][CH2:38][CH2:39][Si:40]([CH3:41])([CH3:42])[CH3:43])[cH:34]3)[CH2:10][N:11]([C:14](=[O:15])[O:16][CH2:17][CH2:18][Si:19]([CH3:20])([CH3:21])[CH3:22])[CH2:12][CH2:13]2)[cH:6][cH:7]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([O:23][CH2:24][c:25]3[cH:26][c:27]4[cH:28][cH:29][cH:30][cH:31][c:32]4[c:33]([OH:35])[cH:34]3)[CH2:10][N:11]([C:14](=[O:15])[O:16][CH2:17][CH2:18][Si:19]([CH3:20])([CH3:21])[CH3:22])[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 86604391beta-trimethylsilylethyl (3RS,4RS)-4-(4-fluorophenyl)-3-[4-(2-trimethylsilyl-ethoxymethoxy)-naphthalen-2-yl-methoxy]-piperidine-1-carboxylate

Product 1

HCID 53737733beta-trimethylsilylethyl (3RS,4RS)-4-(4-fluorophenyl)-3-(4-hydroxy-naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-0df8db31b68f41f78d7019c105233968
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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