Dichloromethane → 1-[1-(4-piperidinyl)-4-piperidinyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

HRID 199806Notes

Reaction equation

HRID 199806 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:15][CH2:16][CH:17]([n:20]3[n:21][c:22](-[c:30]4[cH:31][cH:32][c:33]([O:36][c:37]5[cH:38][cH:39][cH:40][cH:41][cH:42]5)[cH:34][cH:35]4)[c:23]4[c:24]3[n:25][cH:26][n:27][c:28]4[NH2:29])[CH2:18][CH2:19]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:50][CH2:51][Cl:52].[OH:43][C:44]([C:45]([F:46])([F:47])[F:48])=[O:49]>>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:15][CH2:16][CH:17]([n:20]3[n:21][c:22](-[c:30]4[cH:31][cH:32][c:33]([O:36][c:37]5[cH:38][cH:39][cH:40][cH:41][cH:42]5)[cH:34][cH:35]4)[c:23]4[c:24]3[n:25][cH:26][n:27][c:28]4[NH2:29])[CH2:18][CH2:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 223473271-[1-(1-tert-butoxycarbonyl-4-piperidinyl)-4-piperidinyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product 1

HCID 223469961-[1-(4-piperidinyl)-4-piperidinyl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-50c9d1dbe2f54f568f4db0ead457a665
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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