Hydrochloric Acid → 2,2-Difluoro-cyclopropanecarboxylic acid trans-(4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)-amide

HRID 199912Notes

Reaction equation

HRID 199912 reaction equation
[ClH:1].[ClH:2].[ClH:3].[F:28][C:29]1([F:35])[CH:30]([C:32](=[O:33])[OH:34])[CH2:31]1.[O:4]1[CH2:5][CH2:6][c:7]2[c:8]1[c:9]([N:13]1[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][CH:21]3[CH2:22][CH2:23][CH:24]([NH2:27])[CH2:25][CH2:26]3)[CH2:17][CH2:18]1)[n:10][cH:11][cH:12]2>>[O:4]1[CH2:5][CH2:6][c:7]2[c:8]1[c:9]([N:13]1[CH2:14][CH2:15][N:16]([CH2:19][CH2:20][CH:21]3[CH2:22][CH2:23][CH:24]([NH:27][C:32]([CH:30]4[C:29]([F:28])([F:35])[CH2:31]4)=[O:33])[CH2:25][CH2:26]3)[CH2:17][CH2:18]1)[n:10][cH:11][cH:12]2

Participants

4

Reactant 3

HCID 313Hydrochloric Acid3×HCID 27828232,2-Difluorocyclopropane-1-carboxylic acidHCID 580457044-[2-[4-(2,3-Dihydrofuro[2,3-c]pyridin-7-yl)piperazin-1-yl]ethyl]cyclohexan-1-amine

Product 1

HCID 565920842,2-Difluoro-cyclopropanecarboxylic acid trans-(4-{2-[4-(2,3-dihydro-furo[2,3-c]pyridin-7-yl)-piperazin-1-yl]-ethyl}-cyclohexyl)-amide

Sources & evidence

ORD record
ord-bf6d43c029db4fdaae1c7f0c393c890c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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