1,2-Dichloroethane → tert-Butyl 4-(isobutylamino)piperidine-1-carboxylate

HRID 199991Notes

Reaction equation

HRID 199991 reaction equation
[C:1]([O:2][BH-:3]([O:4][C:5](=[O:6])[CH3:7])[O:8][C:9](=[O:10])[CH3:11])(=[O:12])[CH3:13].[CH2:29]([CH:30]([CH3:31])[CH3:32])[NH2:33].[CH3:34][C:35](=[O:36])[OH:37].[Cl:40][CH2:41][CH2:42][Cl:43].[Na+:14].[Na+:39].[O:15]=[C:16]1[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]1.[OH-:38]>>[CH:16]1([NH:33][CH2:29][CH:30]([CH3:31])[CH3:32])[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:20][CH2:21]1

Participants

8

Reactant 7

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 923Sodium ion2×HCID 961HydroxideHCID 6558IsobutylamineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 2724942Triacetoxyborohydride

Product 1

HCID 15380699tert-Butyl 4-(isobutylamino)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-e512a356d1b541cabb68aee2aff98813
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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