Borohydride → tert-butyl (3RS,4RS)-3-(4-benzyloxy-naphthalen-2-ylmethoxy)-4-(3-hydroxymethyl-phenyl)-piperidine-1-carboxylate

HRID 200254Notes

Reaction equation

HRID 200254 reaction equation
[BH4-:44].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]([CH2:19][O:20][CH:21]2[CH2:22][N:23]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:24][CH2:25][CH:26]2[c:27]2[cH:28][c:29]([C:33](=[O:34])[O:35][CH3:36])[cH:30][cH:31][cH:32]2)[cH:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]12.[Li+:45]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11]([CH2:19][O:20][CH:21]2[CH2:22][N:23]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:24][CH2:25][CH:26]2[c:27]2[cH:28][c:29]([CH2:33][OH:34])[cH:30][cH:31][cH:32]2)[cH:12][c:13]2[cH:14][cH:15][cH:16][cH:17][c:18]12

Participants

4

Reactant 3

HCID 28123BorohydrideHCID 28486Lithium ionHCID 54179161HCID 54179161, compound

Product 1

HCID 54536116tert-butyl (3RS,4RS)-3-(4-benzyloxy-naphthalen-2-ylmethoxy)-4-(3-hydroxymethyl-phenyl)-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-cadaecea0b9b421682d46934311f0e0b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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