反应详情

2-Methylpropane-1,3-diol (50 g, 555 mmol) was dissolved in 555 ml pyridine and cooled to 0° C. p-Toluenesulfonyl chloride (212 g, 1110 mmol) was added and stirring was continued over night. 200 ml H2O was added and the reaction was extracted with DCM (2×1L). The combined organic extracts were dried over MgSO4 and evaporated. The product was recrystallized from EtOH/Hex and the product was obtained as a white solid. MS m/z: 399.0 (M+1).

1. additionwas added
2. waitwas continued over night
3. extractionthe reaction was extracted with DCM (2×1L)
4. dry with materialThe combined organic extracts were dried over MgSO4
5. customevaporated
6. customThe product was recrystallized from EtOH/Hex
7. customthe product was obtained as a white solid