1-Chloro-2-methylbutane → Diethyl [4-(1-(3-methylbutyl)-3-methylxanthin-7-yl)butyl]phosphonate

HRID 2006Notes

Reaction equation

HRID 2006 reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]([CH2:11][CH2:12][CH2:13][CH2:14][P:15](=[O:22])([O:19][CH2:20][CH3:21])[O:16][CH2:17][CH3:18])[C:6]=2[C:5](=[O:23])[NH:4][C:3]1=[O:24].[CH3:25][CH:26]([CH2:29][CH3:30])[CH2:27]Cl>>[CH3:25][CH:26]([CH3:27])[CH2:29][CH2:30][N:4]1[C:5](=[O:23])[C:6]2[N:7]([CH2:11][CH2:12][CH2:13][CH2:14][P:15](=[O:22])([O:16][CH2:17][CH3:18])[O:19][CH2:20][CH3:21])[CH:8]=[N:9][C:10]=2[N:2]([CH3:1])[C:3]1=[O:24]

Participants

3

Reactant 2

HCID 120151-Chloro-2-methylbutaneHCID 153824337-(4-Diethylphosphonobutyl)-3-methylxanthine

Product 1

HCID 22446280Diethyl [4-(1-(3-methylbutyl)-3-methylxanthin-7-yl)butyl]phosphonate

Procedure

The title substance was prepared from diethyl [4-(3-methylxanthin-7-yl)-butyl]phosphonate and 2-methylbutyl chloride analogously to Example 1 and chromatographed on silica gel (eluent: dichloromethane/methanol 10:1)

Workup

  1. customchromatographed on silica gel (eluent: dichloromethane/methanol 10:1)

Sources & evidence

ORD record
ord-54829741e0d340c6aeb01d34861de329
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Reaction notes

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