反应详情

温度

0 °C

30 g (0.134 mol) of diethyl 5-hydroxypentylphosphonate (see Example 21) were dissolved in 200 ml of pyridine, and the solution was cooled to 0° C. and treated with stirring with 26.1 g (0.134 mol) of 4-toluenesulfonyl chloride. The reaction mixture was concentrated under reduced pressure, taken up in ethyl acetate, washed several times with 20% strength citric acid solution and water and dried over sodium sulfate. After evaporating the solvent, a pale yellow oil remained, which was employed without further purification.

1. additiontreated
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. washwashed several times with 20% strength citric acid solution and water
4. dry with materialdried over sodium sulfate
5. customAfter evaporating the solvent
6. customwhich was employed without further purification