Tetrahydrofuran → 1-(3,4,5-Trimethoxybenzyl)-2-oxopyrrolidine

HRID 201073Notes

Reaction equation

HRID 201073 reaction equation
[CH3:12][O:13][c:14]1[cH:15][c:16]([CH2:17][Cl:18])[cH:19][c:20]([O:24][CH3:25])[c:21]1[O:22][CH3:23].[CH:7]([Li:8])([CH2:9][CH3:10])[CH3:11].[NH:1]1[C:2](=[O:6])[CH2:3][CH2:4][CH2:5]1.[O:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1>>[N:1]1([CH2:17][c:16]2[cH:15][c:14]([O:13][CH3:12])[c:21]([O:22][CH3:23])[c:20]([O:24][CH3:25])[cH:19]2)[C:2](=[O:6])[CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 120252-PyrrolidoneHCID 774485-(Chloromethyl)-1,2,3-trimethoxybenzeneHCID 178418400CID 53628100

Product 1

HCID 184646621-(3,4,5-Trimethoxybenzyl)-2-oxopyrrolidine

Sources & evidence

ORD record
ord-a962b69f1f7a4d77b939b2028a4e7b4b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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