3-Bromo-5-methylpyridine → 5-Benzyl-3-methylpyridine

HRID 2013216Notes

Reaction equation

HRID 2013216 reaction equation
[CH3:1][c:2]1[cH:7][c:6](Br)[cH:5][n:4][cH:3]1.COc1c(OC)c(OC)cc(C(OCS([CH2:8][c:9]2[cH:14][cH:13][cH:12][cH:11][cH:10]2)(=O)=O)=O)c1>>[CH3:1][c:2]1[cH:7][c:6]([CH2:8][c:9]2[cH:14][cH:13][cH:12][cH:11][cH:10]2)[cH:5][n:4][cH:3]1

Participants

9

Reactant 2

HCID 8177133-Bromo-5-methylpyridineHCID 178492747HCID 178492747, compound

Product 1

HCID 30184895-Benzyl-3-methylpyridine

Reagents, catalysts & solvents 6

HCID 516893Potassium BicarbonateReagentHCID 23683543Potassium t-amylateReagentHCID 17909966Dicyclohexyl(ethyl)phosphineCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 679Dimethyl SulfoxideSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
130 °C

Sources & evidence

ORD record
ord-4aa13a4f70d341e68ca1e2aeaf4cfc9a
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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