3-Bromo-5-methylpyridine → 5-Benzyl-3-methylpyridine

HRID 2013220Notes

Reaction equation

HRID 2013220 reaction equation
COc1c(OC)c(OC)cc(C(OCS([CH2:1][c:2]2[cH:7][cH:6][cH:5][cH:4][cH:3]2)(=O)=O)=O)c1.[CH3:8][c:9]1[cH:14][c:13](Br)[cH:12][n:11][cH:10]1>>[CH3:8][c:9]1[cH:14][c:13]([CH2:1][c:2]2[cH:7][cH:6][cH:5][cH:4][cH:3]2)[cH:12][n:11][cH:10]1

Participants

9

Reactant 2

HCID 8177133-Bromo-5-methylpyridineHCID 178492747HCID 178492747, compound

Product 1

HCID 30184895-Benzyl-3-methylpyridine

Reagents, catalysts & solvents 6

HCID 516893Potassium BicarbonateReagentHCID 23683543Potassium t-amylateReagentHCID 17909966Dicyclohexyl(ethyl)phosphineCatalystHCID 178455864HCID 178455864, compoundCatalystHCID 7921Gamma-ValerolactoneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
130 °C

Sources & evidence

ORD record
ord-ff35984e6e7b46e898bb8a6cb39c7151
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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