Dimethylformamide → 5-{1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-(1-methyl-4-piperidinyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

HRID 201404Notes

Reaction equation

HRID 201404 reaction equation
[C:36](=[O:37])([O-:38])[O-:39].[CH3:1][c:2]1[cH:3][c:4]([CH2:8][C:9](=[O:10])[N:11]2[CH2:12][CH2:13][c:14]3[cH:15][c:16](-[c:20]4[cH:21][n:22]([CH:30]5[CH2:31][CH2:32][NH:33][CH2:34][CH2:35]5)[c:23]5[n:24][cH:25][n:26][c:27]([NH2:29])[c:28]45)[cH:17][cH:18][c:19]32)[cH:5][cH:6][cH:7]1.[Cs+:40].[Cs+:41].[I:42][CH3:43].[O:44]=[CH:45][N:46]([CH3:47])[CH3:48]>>[CH3:1][c:2]1[cH:3][c:4]([CH2:8][C:9](=[O:10])[N:11]2[CH2:12][CH2:13][c:14]3[cH:15][c:16](-[c:20]4[cH:21][n:22]([CH:30]5[CH2:31][CH2:32][N:33]([CH3:36])[CH2:34][CH2:35]5)[c:23]5[n:24][cH:25][n:26][c:27]([NH2:29])[c:28]45)[cH:17][cH:18][c:19]32)[cH:5][cH:6][cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 668236435-{1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-(4-piperidinyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Product 1

HCID 668235865-{1-[(3-methylphenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-(1-methyl-4-piperidinyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Sources & evidence

ORD record
ord-c6ad1431b636447986c8b042ed27c4d9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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