2-Aminopyrimidine-5-boronic acid, pinacol ester → HCID 178508374, compound

HRID 2014809Notes

Reaction equation

HRID 2014809 reaction equation

CC1(C(C)(C)OB([c:1]2[cH:7][n:6][c:4]([NH2:5])[n:3][cH:2]2)O1)C.[Cl:8][CH2:9][CH2:10][c:11]1[c:17](Cl)[n:16][c:15]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[n:14][c:12]1[Cl:13]>>[NH2:5][c:4]1[n:6][cH:7][c:1]([c:17]2[c:11]([CH2:10][CH2:9][Cl:8])[c:12]([Cl:13])[n:14][c:15]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[n:16]2)[cH:2][n:3]1

Participants

8

Reactant 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol ester

HCID 569733604-(4,6-Dichloro-5-(2-chloroethyl)pyrimidin-2-yl)morpholine

Product 1

HCID 178508374HCID 178508374, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagent

HCID 25953Cesium fluorideReagent

HCID 10876480Bis(tri-o-tolylphosphine)palladium(II) DichlorideCatalyst

HCID 312751,4-DioxaneSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 60 °C

Sources & evidence

ORD record: ord-c3c442755c684fba99c74ed012302807
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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