1-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → HCID 178481807, compound

HRID 2016117Notes

Reaction equation

HRID 2016117 reaction equation

Br[c:1]1[n:5]([CH2:6][c:7]2[cH:12][cH:11][cH:10][cH:9][cH:8]2)[n:4][n:3][n:2]1.[CH3:13][n:14]1[c:18](B2OC(C)(C)C(C)(C)O2)[cH:17][cH:16][n:15]1>>[CH3:13][n:14]1[c:18]([c:1]2[n:5]([CH2:6][c:7]3[cH:12][cH:11][cH:10][cH:9][cH:8]3)[n:4][n:3][n:2]2)[cH:17][cH:16][n:15]1

Participants

8

Reactant 2

HCID 49129081-methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

HCID 109775211-benzyl-5-bromo-1H-tetrazole

Product 1

HCID 178481807HCID 178481807, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagent

HCID 14798Sodium HydroxideReagent

HCID 11714597Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II)Catalyst

HCID 887MethanolSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 80 °C

Sources & evidence

ORD record: ord-5490b3270256405d864429e53ecfe1e2
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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