Trifluoroacetic acid → Trifluoroacetic acid

HRID 20172Notes

Reaction equation

HRID 20172 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C@H:9]1[CH:15]([CH2:16][OH:17])[NH:14][C:13](=[O:18])[C@H:12]([N:19](C(OC(C)(C)C)=O)C(OC(C)(C)C)=O)[CH2:11][CH2:10]1.[C:34]([OH:40])([C:36]([F:39])([F:38])[F:37])=[O:35]>C(Cl)Cl>[NH2:19][C@@H:12]1[CH2:11][CH2:10][C@@H:9]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([F:8])[C:2]=2[F:1])[CH:15]([CH2:16][OH:17])[NH:14][C:13]1=[O:18].[C:34]([OH:40])([C:36]([F:39])([F:38])[F:37])=[O:35]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21114343HCID 21114343, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 66939139HCID 66939139, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-7-(hydroxymethyl)-2-oxoazepan-3-yl]imidodicarbonate (100 mg, 0.213 mmol) was diluted DCM (30 mL) and TFA (8 mL) was added. After 2 h, the reaction was concentrated to give the title compound as its TFA salt (57 mg). MS 271.0 (M+1).

Workup

  1. additionwas added
  2. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-4f5e2ee252d04f9599987bd68bc53428
Source dataset
uspto-grants-2010_06
Patent number
US07745427B2

Reaction notes

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