HCID 71696867, compound → HCID 178425085, compound

HRID 2017623Notes

Reaction equation

HRID 2017623 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:11][CH:10]([B-](F)(F)F)[CH2:9]1)=[O:7])([CH3:4])[CH3:3].[CH3:12][c:13]1[n:41][c:32]([O:33][CH2:34][c:35]2[cH:40][cH:39][cH:38][cH:37][cH:36]2)[c:17]([CH2:18][N:19]3[C:30](=[O:31])[c:29]([c:22]4[CH2:21][CH2:20]3)[c:27]([Cl:28])[c:26](Br)[cH:25][c:23]4[Cl:24])[c:15]([CH3:16])[cH:14]1>>[CH3:12][c:13]1[n:41][c:32]([O:33][CH2:34][c:35]2[cH:40][cH:39][cH:38][cH:37][cH:36]2)[c:17]([CH2:18][N:19]3[C:30](=[O:31])[c:29]([c:22]4[CH2:21][CH2:20]3)[c:27]([Cl:28])[c:26]([CH:10]5[CH2:11][N:8]([C:6]([O:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:7])[CH2:9]5)[cH:25][c:23]4[Cl:24])[c:15]([CH3:16])[cH:14]1

Participants

8

Reactant 2

HCID 71696867HCID 71696867, compoundHCID 867237282-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-7-bromo-5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one

Product 1

HCID 178425085HCID 178425085, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagentHCID 25953Cesium fluorideReagentHCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 1140TolueneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
90 °C

Sources & evidence

ORD record
ord-1fe5bc4f574240a58f88014f1b875a35
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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