HCID 56655901, compound → HCID 178456409, compound

HRID 2017627Notes

Reaction equation

HRID 2017627 reaction equation
[CH3:1][c:2]1[n:30][c:21]([O:22][CH2:23][c:24]2[cH:29][cH:28][cH:27][cH:26][cH:25]2)[c:6]([CH2:7][N:8]3[C:19](=[O:20])[c:18]([c:11]4[CH2:10][CH2:9]3)[c:16]([Cl:17])[c:15](Br)[cH:14][c:12]4[Cl:13])[c:4]([CH3:5])[cH:3]1.F[B-]([C:31]([CH2:33][N:34]1[CH2:39][CH2:38][O:37][CH2:36][CH2:35]1)=[CH2:32])(F)F>>[CH3:1][c:2]1[n:30][c:21]([O:22][CH2:23][c:24]2[cH:29][cH:28][cH:27][cH:26][cH:25]2)[c:6]([CH2:7][N:8]3[C:19](=[O:20])[c:18]([c:11]4[CH2:10][CH2:9]3)[c:16]([Cl:17])[c:15]([C:31]([CH2:33][N:34]5[CH2:39][CH2:38][O:37][CH2:36][CH2:35]5)=[CH2:32])[cH:14][c:12]4[Cl:13])[c:4]([CH3:5])[cH:3]1

Participants

8

Reactant 2

HCID 56655901HCID 56655901, compoundHCID 867237282-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-7-bromo-5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one

Product 1

HCID 178456409HCID 178456409, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagentHCID 62657Potassium Phosphate, TribasicReagentHCID 75537289[1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichlormethaneCatalystHCID 1140TolueneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-3fd60eed10174baeaa239f89e3760f9e
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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