Potassium (4-tert-butoxycarbonylpiperazin-1-yl)methyltrifluoroborate → HCID 178425086, compound

HRID 2017636Notes

Reaction equation

HRID 2017636 reaction equation
[K+].[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:14][CH2:13][N:11]([CH2:12][B-](F)(F)F)[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].[CH3:15][c:16]1[n:44][c:35]([O:36][CH2:37][c:38]2[cH:43][cH:42][cH:41][cH:40][cH:39]2)[c:20]([CH2:21][N:22]3[C:33](=[O:34])[c:32]([c:25]4[CH2:24][CH2:23]3)[c:30]([Cl:31])[c:29](Br)[cH:28][c:26]4[Cl:27])[c:18]([CH3:19])[cH:17]1>>[CH3:15][c:16]1[n:44][c:35]([O:36][CH2:37][c:38]2[cH:43][cH:42][cH:41][cH:40][cH:39]2)[c:20]([CH2:21][N:22]3[C:33](=[O:34])[c:32]([c:25]4[CH2:24][CH2:23]3)[c:30]([Cl:31])[c:29]([CH2:12][N:11]5[CH2:13][CH2:14][N:8]([C:6]([O:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:7])[CH2:9][CH2:10]5)[cH:28][c:26]4[Cl:27])[c:18]([CH3:19])[cH:17]1

Participants

8

Reactant 2

HCID 45588144Potassium (4-tert-butoxycarbonylpiperazin-1-yl)methyltrifluoroborateHCID 867237282-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-7-bromo-5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-one

Product 1

HCID 178425086HCID 178425086, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagentHCID 62657Potassium Phosphate, TribasicReagentHCID 60153068Dichloro-(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)palladium(II)CatalystHCID 1140TolueneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
110 °C

Sources & evidence

ORD record
ord-9b46d87f17f2411c91dfd8a717772f15
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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