(R)-(+)-1-Boc-3-aminopyrrolidine → HCID 178452029, compound

HRID 2017669Notes

Reaction equation

HRID 2017669 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:13][C@H:11]([NH2:12])[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].Br[c:14]1[n:22][c:21]([c:17]2[cH:16][cH:15]1)[cH:20]c[cH:19][c:18]2[C:23]#[N:24]>>[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:13][C@H:11]([NH:12][c:17]2[cH:23][n:24][c:14]([N:22]3[CH2:19][CH2:18]O[CH2:20][CH2:21]3)[cH:15][cH:16]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3]

Participants

7

Reactant 2

HCID 854070(R)-(+)-1-Boc-3-aminopyrrolidineHCID 121410810HCID 121410810, compound

Product 1

HCID 178452029HCID 178452029, compound

Reagents, catalysts & solvents 4

HCID 23683543Potassium t-amylateReagentHCID 2734558Bis(tri-tert-butylphosphine)palladium(0)CatalystHCID 312751,4-DioxaneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
120 °C

Sources & evidence

ORD record
ord-042ea82e84394a119372ae2c78a996d2
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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