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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2017932Generated: October 29, 2026

2-Amino-4-bromopyridine → 2-(2-Aminopyridin-4-yl)-4-chlorophenol

https://huagongshe.com/reaction/2017932

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Amino-4-bromopyridineHCID 693282—
Reactant(5-Chloro-2-hydroxyphenyl)boronic Acid (contains varying amounts of Anhydride)HCID 23005362—
ReagentWaterHCID 962—
ReagentCesium fluorideHCID 25953—
CatalystTetrakis(triphenylphosphine)palladiumHCID 11979704—
SolventTetrahydrofuranHCID 8028—
Product2-(2-Aminopyridin-4-yl)-4-chlorophenolHCID 136063619—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-264703e9385546c08bcca8459a8ab2bd
Source note39k HTE dataset from Pfizer