2-Amino-4-bromopyridine → 2-(2-Aminopyridin-4-yl)-4-chlorophenol

HRID 2017932Notes

Reaction equation

HRID 2017932 reaction equation
OB([c:1]1[c:7]([OH:8])[cH:6][cH:5][c:3]([Cl:4])[cH:2]1)O.[NH2:9][c:10]1[n:15][cH:14][cH:13][c:12](Br)[cH:11]1>>[NH2:9][c:10]1[n:15][cH:14][cH:13][c:12]([c:1]2[c:7]([OH:8])[cH:6][cH:5][c:3]([Cl:4])[cH:2]2)[cH:11]1

Participants

8

Reactant 2

HCID 6932822-Amino-4-bromopyridineHCID 23005362(5-Chloro-2-hydroxyphenyl)boronic Acid (contains varying amounts of Anhydride)

Product 1

HCID 1360636192-(2-Aminopyridin-4-yl)-4-chlorophenol

Reagents, catalysts & solvents 5

HCID 962WaterReagentHCID 25953Cesium fluorideReagentHCID 11979704Tetrakis(triphenylphosphine)palladiumCatalystHCID 8028TetrahydrofuranSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-264703e9385546c08bcca8459a8ab2bd
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

Loading…