2-Amino-4-bromopyridine → 2-(2-Aminopyridin-4-yl)-4-chlorophenol

HRID 2017964Notes

Reaction equation

HRID 2017964 reaction equation
[NH2:1][c:2]1[n:7][cH:6][cH:5][c:4](Br)[cH:3]1.OB([c:8]1[c:14]([OH:15])[cH:13][cH:12][c:10]([Cl:11])[cH:9]1)O>>[NH2:1][c:2]1[n:7][cH:6][cH:5][c:4]([c:8]2[c:14]([OH:15])[cH:13][cH:12][c:10]([Cl:11])[cH:9]2)[cH:3]1

Participants

8

Reactant 2

HCID 6932822-Amino-4-bromopyridineHCID 23005362(5-Chloro-2-hydroxyphenyl)boronic Acid (contains varying amounts of Anhydride)

Product 1

HCID 1360636192-(2-Aminopyridin-4-yl)-4-chlorophenol

Reagents, catalysts & solvents 5

HCID 962WaterReagentHCID 14798Sodium HydroxideReagentHCID 86278421[1,1'-bis(di-tert-butylphosphino) ferrocene]dichloropalladium(II)CatalystHCID 6342AcetonitrileSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-afab64ff334341ab991946f7f60c5ebd
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

Loading…