2-Amino-4-bromopyridine → HCID 136387753, compound

HRID 2017978Notes

Reaction equation

HRID 2017978 reaction equation

[NH2:1][c:2]1[n:7][cH:6][cH:5][c:4](Br)[cH:3]1.OB([c:8]1[c:13]([OH:14])[cH:12][cH:11][c:10]([C:15]([F:18])([F:17])[F:16])[cH:9]1)O>>[NH2:1][c:2]1[n:7][cH:6][cH:5][c:4]([c:8]2[c:13]([OH:14])[cH:12][cH:11][c:10]([C:15]([F:18])([F:17])[F:16])[cH:9]2)[cH:3]1

Participants

8

Reactant 2

HCID 6932822-Amino-4-bromopyridine

HCID 59436609(2-Hydroxy-5-(trifluoromethyl)phenyl)boronic acid

Product 1

HCID 136387753HCID 136387753, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagent

HCID 14798Sodium HydroxideReagent

HCID 75537289[1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichlormethaneCatalyst

HCID 6342AcetonitrileSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 100 °C

Sources & evidence

ORD record: ord-873c974eef4f416485e93933ce405b48
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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