2-Amino-4-bromopyridine → HCID 136387753, compound

HRID 2017982Notes

Reaction equation

HRID 2017982 reaction equation
OB([c:1]1[c:6]([OH:7])[cH:5][cH:4][c:3]([C:8]([F:11])([F:10])[F:9])[cH:2]1)O.[NH2:12][c:13]1[n:18][cH:17][cH:16][c:15](Br)[cH:14]1>>[NH2:12][c:13]1[n:18][cH:17][cH:16][c:15]([c:1]2[c:6]([OH:7])[cH:5][cH:4][c:3]([C:8]([F:11])([F:10])[F:9])[cH:2]2)[cH:14]1

Participants

8

Reactant 2

HCID 6932822-Amino-4-bromopyridineHCID 59436609(2-Hydroxy-5-(trifluoromethyl)phenyl)boronic acid

Product 1

HCID 136387753HCID 136387753, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagentHCID 25953Cesium fluorideReagentHCID 86278421[1,1'-bis(di-tert-butylphosphino) ferrocene]dichloropalladium(II)CatalystHCID 1140TolueneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
100 °C

Sources & evidence

ORD record
ord-6c6021965b9246b2910e9c4cfa67a1ad
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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