tert-butyl (3R)-3-aminopiperidine-1-carboxylate → (R)-tert-butyl 3-((3-chloropyridin-2-yl)amino)piperidine-1-carboxylate
Reaction equation
NNC(c1c(N)ccs1)=O.[Cl:1][c:2]1[c:7](Br)[n:6][cH:5][cH:4][cH:3]1.[CH3:8][C:9]([O:12][C:13]([N:15]1[CH2:21][C@H:19]([NH2:20])[CH2:18][CH2:17][CH2:16]1)=[O:14])([CH3:11])[CH3:10]>>[CH3:8][C:9]([O:12][C:13]([N:15]1[CH2:21][C@H:19]([NH:20][c:7]2[c:2]([Cl:1])[cH:3][cH:4][cH:5][n:6]2)[CH2:18][CH2:17][CH2:16]1)=[O:14])([CH3:11])[CH3:10]Participants
7
Reactant 3
Product 1
Reagents, catalysts & solvents 3
Conditions
- Temperature
- 80 °C
Sources & evidence
- ORD record
- ord-e803672adb1b4b9499e7894236985d08
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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