tert-butyl (3R)-3-aminopiperidine-1-carboxylate → (R)-tert-butyl 3-((3-chloropyridin-2-yl)amino)piperidine-1-carboxylate
Reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:14][C@H:12]([NH2:13])[CH2:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].[Cl:15][c:16]1[c:21](Br)[n:20][cH:19][cH:18][cH:17]1.NNC(c1c(N)ccs1)=O>>[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:14][C@H:12]([NH:13][c:21]2[c:16]([Cl:15])[cH:17][cH:18][cH:19][n:20]2)[CH2:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3]Participants
7
Reactant 3
Product 1
Reagents, catalysts & solvents 3
Conditions
- Temperature
- 80 °C
Sources & evidence
- ORD record
- ord-dce529215ec04c8e823d1d917675c223
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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