2-Methylpyridine-4-boronic acid pinacol ester → HCID 178422601, compound

HRID 2018207Notes

Reaction equation

HRID 2018207 reaction equation

I[c:1]1[cH:10][c:9]([c:4]2[cH:3][cH:2]1)[cH:8][cH:7][cH:6][n:5]2.[CH3:11][c:12]1[n:17][cH:16][cH:15][c:14](B2OC(C)(C)C(C)(C)O2)[cH:13]1>>[CH3:11][c:12]1[n:17][cH:16][cH:15][c:14]([c:1]2[cH:10][c:9]([c:4]3[cH:3][cH:2]2)[cH:8][cH:7][cH:6][n:5]3)[cH:13]1

Participants

8

Reactant 2

HCID 164142742-Methylpyridine-4-boronic acid pinacol ester

HCID 203985536-Iodoquinoline

Product 1

HCID 178422601HCID 178422601, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagent

HCID 10796Cesium carbonateReagent

HCID 2734558Bis(tri-tert-butylphosphine)palladium(0)Catalyst

HCID 6342AcetonitrileSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 140 °C

Sources & evidence

ORD record: ord-2371c0768ccd47c98171f6de193043e0
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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