1-methyl-1H-pyrazol-4-amine → HCID 178480805, compound

HRID 2018650Notes

Reaction equation

HRID 2018650 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[C:22]([CH3:24])([CH3:23])[c:21]([c:10]2[CH2:9]1)[n:13]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[n:12][c:11]2Br)=[O:7])([CH3:4])[CH3:3].[CH3:25][n:26]1[n:31][cH:30][c:28]([NH2:29])[cH:27]1>>[CH3:25][n:26]1[n:31][cH:30][c:28]([NH:29][c:11]2[c:10]3[c:21]([C:22]([CH3:24])([CH3:23])[N:8]([C:6]([O:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:7])[CH2:9]3)[n:13]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[n:12]2)[cH:27]1

Participants

8

Reactant 2

HCID 47709901-methyl-1H-pyrazol-4-amineHCID 178451427HCID 178451427, compound

Product 1

HCID 178480805HCID 178480805, compound

Reagents, catalysts & solvents 5

HCID 8058HexaneReagentHCID 236647642-Propanol, 2-methyl-, lithium salt (1:1)ReagentHCID 178492614HCID 178492614, compoundCatalystHCID 64052-Methyl-2-butanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
90 °C

Sources & evidence

ORD record
ord-dbe4849de95c4a029fcff21f26fd7cca
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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