Dichloromethane → [4-[[5-[Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-[4-(pyridin-2-ylmethyl)piperazin-1-yl]methanone

HRID 202000Notes

Reaction equation

HRID 202000 reaction equation
[Cl:50][CH2:51][Cl:52].[OH:1][CH:2]([CH:3]1[N:4]([C:30]([O:31][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:36])[CH:5]([CH2:8][c:9]2[cH:10][cH:11][c:12]([C:15](=[O:16])[N:17]3[CH2:18][CH2:19][N:20]([CH2:23][c:24]4[n:25][cH:26][cH:27][cH:28][cH:29]4)[CH2:21][CH2:22]3)[cH:13][cH:14]2)[CH2:6][CH2:7]1)[c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1.[OH:43][C:44]([C:45]([F:46])([F:47])[F:48])=[O:49]>>[OH:1][CH:2]([CH:3]1[NH:4][CH:5]([CH2:8][c:9]2[cH:10][cH:11][c:12]([C:15](=[O:16])[N:17]3[CH2:18][CH2:19][N:20]([CH2:23][c:24]4[n:25][cH:26][cH:27][cH:28][cH:29]4)[CH2:21][CH2:22]3)[cH:13][cH:14]2)[CH2:6][CH2:7]1)[c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 178451596HCID 178451596, compound

Product 1

HCID 77441374[4-[[5-[Hydroxy(phenyl)methyl]pyrrolidin-2-yl]methyl]phenyl]-[4-(pyridin-2-ylmethyl)piperazin-1-yl]methanone

Sources & evidence

ORD record
ord-b3b22e723b1a43fab03761f506ed6ffc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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