Dichloromethane → N-(4-amino-2-methyl-6-(((1-methylethyl)amino)carbonyl)phenyl)-1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

HRID 202120Notes

Reaction equation

HRID 202120 reaction equation
[Cl:1][c:2]1[c:3](-[n:8]2[n:9][c:10]([C:32]([F:33])([F:34])[F:35])[cH:11][c:12]2[C:13](=[O:14])[NH:15][c:16]2[c:17]([CH3:31])[cH:18][c:19]([N+:28]([O-:29])=[O:30])[cH:20][c:21]2[C:22](=[O:23])[NH:24][CH:25]([CH3:26])[CH3:27])[n:4][cH:5][cH:6][cH:7]1.[Cl:43][CH2:44][Cl:45].[OH:36][C:37]([C:38]([F:39])([F:40])[F:41])=[O:42].[Zn:46]>>[Cl:1][c:2]1[c:3](-[n:8]2[n:9][c:10]([C:32]([F:33])([F:34])[F:35])[cH:11][c:12]2[C:13](=[O:14])[NH:15][c:16]2[c:17]([CH3:31])[cH:18][c:19]([NH2:28])[cH:20][c:21]2[C:22](=[O:23])[NH:24][CH:25]([CH3:26])[CH3:27])[n:4][cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 23994ZincHCID 18446929HCID 18446929, compound

Product 1

HCID 10227689N-(4-amino-2-methyl-6-(((1-methylethyl)amino)carbonyl)phenyl)-1-(3-chloro-2-pyridinyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Sources & evidence

ORD record
ord-a61be0211ac4483b876e2acda8ab4e92
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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