反应详情

Benzyl 4-({[(2,2-dimethoxyethyl)amino]carbonyl}amino)piperidin-1-carboxylate (0.37 g) obtained in Example 16a) was dissolved in water (5 mL) and methanol (10 mL), and 1N hydrochloric acid (5 mL) was added thereto. The mixture was stirred at room temperature for 3 days. After the reaction mixture was concentrated under reduced pressure, the residue was diluted with water, and extracted with ethyl acetate. The extract was washed with water and saturated saline solution, and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain the title compound (0.27 g, 90%) as a colorless solid.

1. concentrationAfter the reaction mixture was concentrated under reduced pressure
2. additionthe residue was diluted with water
3. extractionextracted with ethyl acetate
4. washThe extract was washed with water and saturated saline solution
5. dry with materialdried over anhydrous sodium sulfate
6. distillationthe solvent was distilled off under reduced pressure