6-Bromoquinoline → HCID 178481932, compound

HRID 2022817Notes

Reaction equation

HRID 2022817 reaction equation

[CH3:1][n:2]1[c:7](B2OC(C)(C)C(C)(C)O2)[cH:6][c:4]([NH2:5])[n:3]1.Br[c:8]1[cH:17][c:16]([c:11]2[cH:10][cH:9]1)[cH:15][cH:14][cH:13][n:12]2>>[CH3:1][n:2]1[c:7]([c:8]2[cH:17][c:16]([c:11]3[cH:10][cH:9]2)[cH:15][cH:14][cH:13][n:12]3)[cH:6][c:4]([NH2:5])[n:3]1

Participants

8

Reactant 2

HCID 792436-Bromoquinoline

HCID 178481931HCID 178481931, compound

Product 1

HCID 178481932HCID 178481932, compound

Reagents, catalysts & solvents 5

HCID 962WaterReagent

HCID 14798Sodium HydroxideReagent

HCID 60153068Dichloro-(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)palladium(II)Catalyst

HCID 6342AcetonitrileSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 80 °C

Sources & evidence

ORD record: ord-6fd360e8bf364c328a21540f394fd42c
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Reaction notes

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