1-(4-Benzylpiperazin-1-yl)tetrahydropyrimidin-2(1H)-one → 1-(Piperazin-1-yl)tetrahydropyrimidin-2(1H)-one

Participants

Reaction Steps

To a solution of 1-(4-benzylpiperazin-1-yl)tetrahydropyrimidin-2(1H)-one obtained in Example 25a) (0.82 g) was added 20% palladium hydroxide on carbon (containing 50% water; 0.20 g), and the mixture was stirred at room temperature for 60 hours under a hydrogen atmosphere. The reaction mixture was filtered, and the solvent was distilled off under reduced pressure to obtain the title compound (0.56 g, quantitative) as colorless crystals.

Provenance & Evidence