1-(4-Benzylpiperazin-1-yl)tetrahydropyrimidin-2(1H)-one → 1-(Piperazin-1-yl)tetrahydropyrimidin-2(1H)-one

HRID 20229Notes

Reaction equation

HRID 20229 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([N:14]2[CH2:19][CH2:18][CH2:17][NH:16][C:15]2=[O:20])[CH2:10][CH2:9]1)C1C=CC=CC=1>[OH-].[OH-].[Pd+2]>[N:11]1([N:14]2[CH2:19][CH2:18][CH2:17][NH:16][C:15]2=[O:20])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 1

HCID 672325181-(4-Benzylpiperazin-1-yl)tetrahydropyrimidin-2(1H)-one

Product 1

HCID 672326581-(Piperazin-1-yl)tetrahydropyrimidin-2(1H)-one

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

To a solution of 1-(4-benzylpiperazin-1-yl)tetrahydropyrimidin-2(1H)-one obtained in Example 25a) (0.82 g) was added 20% palladium hydroxide on carbon (containing 50% water; 0.20 g), and the mixture was stirred at room temperature for 60 hours under a hydrogen atmosphere. The reaction mixture was filtered, and the solvent was distilled off under reduced pressure to obtain the title compound (0.56 g, quantitative) as colorless crystals.

Workup

  1. filtrationThe reaction mixture was filtered
  2. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-f9f17122772c4d6faa47d4d5cd0a9769
Source dataset
uspto-grants-2010_06
Patent number
US07745623B2

Reaction notes

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