2-Cyclohexen-1-one, 4-methyl-, (R)- → Tert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylate

HRID 2023501Notes

Reaction equation

HRID 2023501 reaction equation
[CH3:17][C@H:18]1[CH:24]=[CH:23][C:21](=[O:22])[CH2:20][CH2:19]1.[CH3:1][c:2]1[c:16](B2O[C:29]([CH3:31])([CH3:30])[C:26]([CH3:28])([CH3:27])[O:25]2)[c:6]3[c:5]([n:9]([C@@H:10]4[O:15][CH2:14][CH2:13][CH2:12][CH2:11]4)[n:8][cH:7]3)[cH:4][c:3]1Cl>>[CH3:1][c:2]1[c:16]([CH:21]2[CH2:23][c:24]3[c:18]([c:17](N4CCN(C([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:22])[CH2:31][CH2:30]4)ncn3)[CH2:19][CH2:20]2)[c:6]5[c:5]([n:9]([CH:10]6[O:15][CH2:14][CH2:13][CH2:12][CH2:11]6)[n:8][cH:7]5)[cH:4][cH:3]1

Participants

7

Reactant 2

HCID 111053342-Cyclohexen-1-one, 4-methyl-, (R)-HCID 178427897HCID 178427897, compound

Product 1

HCID 139388538Tert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylate

Reagents, catalysts & solvents 4

HCID 25953Cesium fluorideReagentHCID 178420231HCID 178420231, compoundCatalystHCID 312751,4-DioxaneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
40 °C

Sources & evidence

ORD record
ord-adc2a16b3424495f8d9207a883c5d5ba
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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