2-Cyclohexen-1-one, 4-methyl-, (R)- → Tert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylate

HRID 2023519Notes

Reaction equation

HRID 2023519 reaction equation
[CH3:1][c:2]1[c:16](B2O[C:21]([CH3:23])([CH3:22])[C:18]([CH3:20])([CH3:19])[O:17]2)[c:6]3[c:5]([n:9]([C@@H:10]4[O:15][CH2:14][CH2:13][CH2:12][CH2:11]4)[n:8][cH:7]3)[cH:4][c:3]1Cl.[CH3:24][C@H:25]1[CH:31]=[CH:30][C:28](=[O:29])[CH2:27][CH2:26]1>>[CH3:1][c:2]1[c:16]([CH:28]2[CH2:30][c:31]3[c:25]([c:24](N4CCN(C([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:29])[CH2:23][CH2:22]4)ncn3)[CH2:26][CH2:27]2)[c:6]5[c:5]([n:9]([CH:10]6[O:15][CH2:14][CH2:13][CH2:12][CH2:11]6)[n:8][cH:7]5)[cH:4][cH:3]1

Participants

7

Reactant 2

HCID 111053342-Cyclohexen-1-one, 4-methyl-, (R)-HCID 178427897HCID 178427897, compound

Product 1

HCID 139388538Tert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylate

Reagents, catalysts & solvents 4

HCID 2724141Tetrabutylammonium FluorideReagentHCID 178420231HCID 178420231, compoundCatalystHCID 312751,4-DioxaneSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
40 °C

Sources & evidence

ORD record
ord-a3151d018aa74094a2289dc481db8a00
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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