HCID 178422847, compound → Tert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylate

HRID 2024357Notes

Reaction equation

HRID 2024357 reaction equation
[CH3:1][c:2]1[c:16](B(O)O)[c:6]2[c:5]([n:9]([CH:10]3[O:15][CH2:14][CH2:13][CH2:12][CH2:11]3)[n:8][cH:7]2)[cH:4][cH:3]1.[CH3:17][C:18]([O:21][C:22]([N:24]1[CH2:29][CH2:28][N:27]([c:30]2[c:39]([c:34]3[n:33][cH:32][n:31]2)[CH2:38][CH2:37][CH:36]=[CH:35]3)[CH2:26][CH2:25]1)=[O:23])([CH3:20])[CH3:19]>>[CH3:1][c:2]1[c:16]([CH:36]2[CH2:35][c:34]3[c:39]([c:30]([N:27]4[CH2:28][CH2:29][N:24]([C:22]([O:21][C:18]([CH3:20])([CH3:19])[CH3:17])=[O:23])[CH2:25][CH2:26]4)[n:31][cH:32][n:33]3)[CH2:38][CH2:37]2)[c:6]5[c:5]([n:9]([CH:10]6[O:15][CH2:14][CH2:13][CH2:12][CH2:11]6)[n:8][cH:7]5)[cH:4][cH:3]1

Participants

7

Reactant 2

HCID 178422847HCID 178422847, compoundHCID 178452263HCID 178452263, compound

Product 1

HCID 139388538Tert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylate

Reagents, catalysts & solvents 4

HCID 3251421Potassium bis(trimethylsilyl)amideReagentHCID 634876Binap, (A+-)-CatalystHCID 178443481HCID 178443481, compoundCatalystHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-b900db9e0e6b47be9a0b920662ecb6e2
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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