Dichloromethane → 1-[4-(2-Chloro-7-methylquinazolin-4-yl)piperazin-1-yl]-2-hydroxy-4-methylpentan-1-one

HRID 202442Notes

Reaction equation

HRID 202442 reaction equation
[CH3:14][CH2:15][N:16]([CH2:17][CH3:18])[CH2:19][CH3:20].[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([CH3:13])[cH:7][cH:8][c:9]2[c:10]([Cl:12])[n:11]1.[Cl:35][CH2:36][Cl:37].[OH:21][CH:22]([C:23](=[O:24])[N:25]1[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]1)[CH2:31][CH:32]([CH3:33])[CH3:34]>>[Cl:1][c:2]1[n:3][c:4]2[cH:5][c:6]([CH3:13])[cH:7][cH:8][c:9]2[c:10]([N:28]2[CH2:27][CH2:26][N:25]([C:23]([CH:22]([OH:21])[CH2:31][CH:32]([CH3:33])[CH3:34])=[O:24])[CH2:30][CH2:29]2)[n:11]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 219419832,4-Dichloro-7-methylquinazolineHCID 670982582-Hydroxy-4-methyl-1-piperazin-1-yl-pentan-1-one

Product 1

HCID 872682201-[4-(2-Chloro-7-methylquinazolin-4-yl)piperazin-1-yl]-2-hydroxy-4-methylpentan-1-one

Sources & evidence

ORD record
ord-27ac1b998cf540c3b3f6e5f03eb6fb29
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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