HCID 178422847, compound → Tert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylate

HRID 2024428Notes

Reaction equation

HRID 2024428 reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([c:14]2[c:23]([c:18]3[n:17][cH:16][n:15]2)[CH2:22][CH2:21][CH:20]=[CH:19]3)[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].[CH3:24][c:25]1[c:39](B(O)O)[c:29]2[c:28]([n:32]([CH:33]3[O:38][CH2:37][CH2:36][CH2:35][CH2:34]3)[n:31][cH:30]2)[cH:27][cH:26]1>>[CH3:24][c:25]1[c:39]([CH:20]2[CH2:19][c:18]3[c:23]([c:14]([N:11]4[CH2:12][CH2:13][N:8]([C:6]([O:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:7])[CH2:9][CH2:10]4)[n:15][cH:16][n:17]3)[CH2:22][CH2:21]2)[c:29]5[c:28]([n:32]([CH:33]6[O:38][CH2:37][CH2:36][CH2:35][CH2:34]6)[n:31][cH:30]5)[cH:27][cH:26]1

Participants

7

Reactant 2

HCID 178422847HCID 178422847, compoundHCID 178452263HCID 178452263, compound

Product 1

HCID 139388538Tert-butyl 4-[7-[5-methyl-1-(oxan-2-yl)indazol-4-yl]-5,6,7,8-tetrahydroquinazolin-4-yl]piperazine-1-carboxylate

Reagents, catalysts & solvents 4

HCID 1049PyridineReagentHCID 634876Binap, (A+-)-CatalystHCID 178443481HCID 178443481, compoundCatalystHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-3363de676de94bfd84072dd57f7a5600
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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