N-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamide → N-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

HRID 2025498Notes

Reaction equation

HRID 2025498 reaction equation
[Cl:1][c:2]1[n:16][c:15](Cl)[c:5]2[c:4]([n:8]([CH:9]3[O:14][CH2:13][CH2:12][CH2:11][CH2:10]3)[n:7][cH:6]2)[cH:3]1.[CH3:17][N:18]([S:27]([CH3:30])(=[O:29])=[O:28])[c:19]1[c:24]([CH2:25][NH2:26])[cH:23][cH:22][cH:21][cH:20]1>>[CH3:17][N:18]([S:27]([CH3:30])(=[O:29])=[O:28])[c:19]1[c:24]([CH2:25][NH:26][c:15]2[c:5]3[c:4]([n:8]([CH:9]4[O:14][CH2:13][CH2:12][CH2:11][CH2:10]4)[n:7][cH:6]3)[cH:3][c:2]([Cl:1])[n:16]2)[cH:23][cH:22][cH:21][cH:20]1

Participants

6

Reactant 2

HCID 45480190N-(2-(Aminomethyl)phenyl)-N-methylmethanesulfonamideHCID 1254824194,6-dichloro-1-[(2R)-oxan-2-yl]pyrazolo[4,3-c]pyridine

Product 1

HCID 118512378N-(2-(((6-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[4,3-c]pyridin-4-yl)amino)methyl)phenyl)-N-methylmethanesulfonamide

Reagents, catalysts & solvents 3

HCID 4339838N'''-(1,1-Dimethylethyl)-N,N',N''-tris(tris(dimethylamino)phosphoranylidene)phosphorimidic triamideReagentHCID 64052-Methyl-2-butanolSolventHCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature
80 °C

Sources & evidence

ORD record
ord-0ac893e9eeed4a71adb383d12a33d4ab
Source dataset
39k HTE dataset from Pfizer
Original link
View source

Reaction notes

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