Hydrochloric Acid → methyl 1H-tetrazol-1-ylacetate

HRID 20268Notes

Reaction equation

HRID 20268 reaction equation
[N:1]1([CH2:6][C:7]([OH:9])=[O:8])[CH:5]=[N:4][N:3]=[N:2]1.Cl.O1CCOC[CH2:12]1>CO>[N:1]1([CH2:6][C:7]([O:9][CH3:12])=[O:8])[CH:5]=[N:4][N:3]=[N:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 5432071-Tetrazolylacetic acid

Product 1

HCID 3153776methyl 1H-tetrazol-1-ylacetate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of tetrazol-1-yl acetic acid (5 g, 39 mmol) and 4M hydrochloric acid in dioxan (100 μL) in methanol (50 mL) was heated under reflux for 18 hours. The cooled mixture was evaporated under reduced pressure to provide the title compound.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. customThe cooled mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-2eec8cc3221c4243826d62a42e0801a2
Source dataset
uspto-grants-2010_06
Patent number
US07745630B2

Reaction notes

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