Pyridine → (3SR,4RS)-3-(3,4-Dichloro-phenyl)-4-[(3-fluoro-4-trifluoromethyl-benzyl)-methyl-amino]-pyrrolidine-1-carbonyl chloride

HRID 202718Notes

Reaction equation

HRID 202718 reaction equation
[Cl:13][c:14]1[cH:15][c:16]([CH:21]2[CH:22]([N:26]([CH3:27])[CH2:28][c:29]3[cH:30][c:31]([F:39])[c:32]([C:35]([F:36])([F:37])[F:38])[cH:33][cH:34]3)[CH2:23][NH:24][CH2:25]2)[cH:17][cH:18][c:19]1[Cl:20].[Cl:1][C:2]([Cl:3])([O:4][C:5]([O:6][C:7]([Cl:9])([Cl:10])[Cl:11])=[O:8])[Cl:12].[Cl:46][CH2:47][Cl:48].[cH:40]1[cH:41][cH:42][n:43][cH:44][cH:45]1>>[O:6]=[C:7]([Cl:10])[N:24]1[CH2:23][CH:22]([N:26]([CH3:27])[CH2:28][c:29]2[cH:30][c:31]([F:39])[c:32]([C:35]([F:36])([F:37])[F:38])[cH:33][cH:34]2)[CH:21]([c:16]2[cH:15][c:14]([Cl:13])[c:19]([Cl:20])[cH:18][cH:17]2)[CH2:25]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 94429TriphosgeneHCID 75231672[(3RS,4SR)-4-(3,4-Dichloro-phenyl)-pyrrolidin-3-yl]-(3-fluoro-4-trifluoromethyl-benzyl)-methyl-amine

Product 1

HCID 72253484(3SR,4RS)-3-(3,4-Dichloro-phenyl)-4-[(3-fluoro-4-trifluoromethyl-benzyl)-methyl-amino]-pyrrolidine-1-carbonyl chloride

Sources & evidence

ORD record
ord-c877adca524c4614ad2c264bd11792b0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…