Dimethyl Carbonate → [2-Chloro-6-(4-trifluoromethyl-phenyl)-pyridin-4-yl]-acetic acid methyl ester

HRID 202724Notes

Reaction equation

[CH3:27][O:28][C:29](=[O:30])[O:31][CH3:32].[CH3:2][CH:3]([N-:4][CH:5]([CH3:6])[CH3:7])[CH3:8].[Cl:9][c:10]1[n:11][c:12](-[c:17]2[cH:18][cH:19][c:20]([C:23]([F:24])([F:25])[F:26])[cH:21][cH:22]2)[cH:13][c:14]([CH3:16])[cH:15]1.[Li+:1]>>[Cl:9][c:10]1[n:11][c:12](-[c:17]2[cH:18][cH:19][c:20]([C:23]([F:24])([F:25])[F:26])[cH:21][cH:22]2)[cH:13][c:14]([CH2:16][C:29]([O:28][CH3:27])=[O:30])[cH:15]1

Participants

Reactant 4

HCID 12021Dimethyl Carbonate

HCID 28486Lithium ion

HCID 5062348Diisopropylamide

HCID 574686282-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyridine

Product 1

HCID 59161716[2-Chloro-6-(4-trifluoromethyl-phenyl)-pyridin-4-yl]-acetic acid methyl ester

Sources & evidence

ORD record: ord-a43e61a0b71543e1a42cb291e77ef528
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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